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SUBA™ Bioavailability Technology

SUBA technology is a novel technology for enhancing the bioavailability of poorly soluble drugs. The technology utilizes a solid dispersion of drug in a polymer that improves the dissolution of poorly soluble drugs compared to their normal crystalline form. This results in an improvement of the absorption in the gastrointestinal tract to achieve “super bioavailability” compared to conventional formulations.

Potential benefits of SUBA technology include:

  • Increased bioavailability
  • Reduced intra/inter-patient variability in pharmacokinetics

SUBA technology has been successfully applied to improve the bioavailability of the poorly soluble anti-fungal drug itraconazole which has variable pharmacokinetics. SUBA-Itraconazole and has received regulatory approval in the US, Australia and a number of European and South American markets. The brand name is TOLSURA® in the US and LOZANOC® in Australia.

Itraconazole drug substance prior to processing.           

Itraconazole drug substance prior to processing.

 

SUBA™ Itraconazole solid dispersions containing 40% Itraconazole: 60% HP-50

SUBA™ Itraconazole solid dispersions containing 40% Itraconazole: 60% HP-50