SUBA™ Bioavailability Technology

SUBA dispersion

SUBA technology is proprietary technology that improves the oral bioavailability of poorly soluble drugs.

The technology utilises a solid dispersion of drug in a polymer (see SUBA™ technology particle picture) to improve the absorption of drugs in the gastrointestinal tract to achieve “super bioavailability” compared to conventional formulations.  This dispersion improves the dissolution of poorly soluble drugs compared to their normal crystalline form.

SUBA™ technology has been applied to improving the oral absorption of itraconazole. SUBA™ Itraconazole (improved bioavailability itraconazole capsules) has approximately double the bioavailability of the innovator
formulation and can be taken without regard to meals.

Itraconazole drug substance prior to processing. SUBA™ Itraconazole solid dispersions containing 40% Itraconazole: 60% HP-50
Itraconazole drug substance prior to processing.  SUBA™ Itraconazole solid dispersions containing 40% Itraconazole: 60% HP-50

To Top